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As the tablet disintegrates, the instrument is set to maintain a small force for a determined period of time. The plots of some distance traveled by the probe generated with the instrument’s software provide disintegration profile of the tablets as a function of time. The plot facilitates calculation of the start and end-point of the tablet disintegration.
The same does not hold true for poorly water-soluble or poorly absorbable drugs. Such agents should be given orally, because both the volume of fluid for dissolution and the absorbing surface are much larger in the small intestine than in the oral cavity. |
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