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As the tablet disintegrates, the instrument is set to maintain a small force for a determined period of time. The plots of some distance traveled by the probe generated with the instrument’s software provide disintegration profile of the tablets as a function of time. The plot facilitates calculation of the start and end-point of the tablet disintegration.
Hallucinations may also occur as adverse effects after intake of other substances, e. g. , scopolamine and other centrally active parasympatholytics. The popular psychostimulant, methylenedioxy- methamphetamine (MDMA, “ecstasy”) acutely increases neuronal dopamine and norepinephrine release and causes a delayed and selective degeneration of forebrain 5-HT nerve terminals.

 

The same does not hold true for poorly water-soluble or poorly absorbable drugs. Such agents should be given orally, because both the volume of fluid for dissolution and the absorbing surface are much larger in the small intestine than in the oral cavity.
For instances, morphine (p. 210), given in the appropriate dose, affords excellent pain relief by influencing nociceptive pathways in the CNS. In excessive doses, it inhibits the respiratory center and makes apnea imminent. The dose dependence of both effects can be graphed in the form of dose-response curves (DRC).

 

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