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A freeze-dried wafer is a quick-dissolving, thin matrix that contains a medicinal agent that does not need water for swallowing. This fragile dosage form requires unit-dose packaging to ensure physical stability. The wafer disintegrates instantaneously in the oral cavity and releases drug, which dissolves or disperses in the saliva.
Norepinephrine differs from epinephrine by its high affinity for ?-receptors and low affinity for ?2-receptors. In contrast, isoproterenol has high affinity for ?-receptors, but virtually none for ?-receptors (A). norepinephrine ?, ?1 epinephrine ?, ?1, ?2 isoproterenol.

 

Because of its quaternary nitrogen, this drug does not enter the brain and requires parenteral administration. Its spasmolytic action is especially marked because of additional ganglionic blocking and direct muscle-relaxant actions.
The exact cause of these complaints is unknown; however, a disturbance in cranial blood flow is the likely underlying pathogenetic mechanism. In addition to an often inherited predisposition, precipitating factors are required to provoke an attack, e. g. , psychic stress, lack of sleep, certain foods.

 

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