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“Juvenile onset” (type I) diabetes mellitus is caused by the destruction of insulin- producing B cells in the pancreas, necessitating replacement of insulin (daily dose approx. 40 U, equivalent to approx. 1. 6 mg).
Mitosis is preceded by replication of chromosomes (DNA synthesis) and increased protein synthesis (RNA synthesis). Existing DNA (gray) serves as a template for the synthesis of new (blue) DNA or RNA. De novo synthesis may be inhibited by: Damage to the template (1). Alkylating cytostatics are reactive compounds that transfer alkyl residues into a covalent bond with DNA.

 

Upon electrical excitation, a characteristic change occurs in membrane potential— the action potential (AP). Its underlying cause is a sequence of transient ionic currents. During rapid depolarization (Phase 0), there is a short-lived influx of Na+ through the membrane. A subsequent transient influx of Ca2+ (as well as of Na+) maintains the depolarization (Phase 2, plateau of AP).
The arterial pressure generates the driving force for perfusion of tissues and organs. Blood draining from the latter collects in the low-pressure system and is pumped back by the heart into the high-pressure system. Chronic hypotension (systolic BP < 105 mmHg). Primary idiopathic hypotension generally has no clinical importance.

 

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