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Its activity spectrum includes significant psychomotor stimulation, depression of appetite, and anxiolysis. Buspirone also has anxiolytic properties thought to be mediated by central presynaptic 5-HT1A receptors. Ondansetron, an antagonist at the 5-HT3 receptor, possesses striking effectiveness against cytotoxic drug-induced emesis, evident both at the start of and during cytostatic therapy.
A decrease in the concentration of albumin (liver disease, nephrotic syndrome, poor general condition) leads to altered pharmacokinetics of drugs that are highly bound to albumin. Plasma protein-bound drugs that are substrates for transport carriers can be cleared from blood at great velocity, e.g., p-aminohippurate by the renal tubule and sulfobromophthalein by the liver. |
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