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Thus, typical adverse effects occur: Loss of hair results from injury to hair follicles; gastrointestinal disturbances, such as diarrhea, from inadequate replacement of enterocytes whose life span is limited to a few days; nausea and vomiting from stimulation of area postrema chemoreceptors; and lowered resistance to infection from weakening of the immune system .
Acute dystonias occur immediately after neuroleptization and are manifested by motor impairments, particularly in the head, neck, and shoulder region. After several days to months, a parkinsonian syndrome (pseudoparkinsonism) or akathisia (motor restlessness) may develop. All these disturbances can be treated by administration of antiparkinson drugs of the anticholinergic type, such as biperiden.

 

At this site, molecular oxygen is used in oxidative reactions. Because these enzymes can catalyze either hydroxylation or oxidative cleavage of -N-C- or -O-Cbonds, they are referred to as “mixedfunction” oxidases or hydroxylases. The essential component of this enzyme system is cytochrome P450, which in its oxidized state binds drug substrates (RH).
There are several vitamin K derivatives of different origins: K1 (phytomenadione) from chlorophyllous plants; K2 from gut bacteria; and K3 (menadione) synthesized chemically. All are hydrophobic and require bile acids for absorption.

 

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