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The same process is repeated when the drug penetrates the axonal membrane (axolemma) into the axoplasm, from which it exerts its action on the sodium channel, and again when it diffuses out of the endoneural space through the unfenestrated endothelium of capillaries into the blood.
Indications: pulmonary edema (added advantage of i. v. injection in left ventricular failure: immediate dilation of venous capacitance vessels preload reduction); refractoriness to thiazide diuretics, e. g. , in renal hypovolemic failure with creatinine clearance reduction (<30 mL/min); prophylaxis of acute renal hypovolemic failure; hypercalcemia.
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