Drug Name Methotrexate

This property is exploited therapeutically when loss of blood necessitates refilling of the vascular bed, e.g., by infusion of dextran solutions. The vascular space is, moreover, predominantly occupied by substances bound with high affinity to plasma proteins; determination of the plasma volume with protein-bound dyes).
Whether this effect could also be achieved by an ?-sympathomimetic remains debatable. In the very rare asympathotonic form, use of sympathomimetics would certainly be reasonable.

 

This formulation can be meaningful when high drug concentrations are required at the skin surface (e.g., neomycin ointment for bacterial skin infections). As a rule, drugs reach their target organs via the blood. Therefore, they must first enter the blood, usually the venous limb of the circulation. There are several possible sites of entry.
In these forms of rhythm disorders, antiarrhythmics of the local anesthetic, Na+-channel blocking type (B) are used for both prophylaxis and therapy. Local anesthetics inhibit electrical excitation of nociceptive nerve fibers; concomitant cardiac inhibition (cardiodepression) is an unwanted effect. However, in certain types of arrhythmias (see above), this effect is useful.